Home Alzheimer’s Disease Trial in Progress: NeoADAURA Will Examine Neoadjuvant Osimertinib in Resectable EGFR+ NSCLC

Trial in Progress: NeoADAURA Will Examine Neoadjuvant Osimertinib in Resectable EGFR+ NSCLC

Neoadjuvant osimertinib (Tagrisso), either as monotherapy or in combination with platinum-based chemotherapy, will be compared against chemotherapy alone in patients with resectable, stage II to IIIB non–small cell lung cancer (NSCLC) whose tumors harbor EGFR mutations in the phase 3 NeoADAURA trial (NCT04351555), according to data presented at the International Association for the Study of Lung Cancer 2020 World Conference on Lung Cancer (WCLC).1

The primary end point of the study is focused on evaluating major pathological response (MPR), which is defined as less than or equal to 10% of residual cancer cells in the lung tumor specimen following surgery per central assessment. The study sample was based on approximately a 90% power to identify a statistically significant 20 percentage point difference in MPR, with a 2-sided overall significance level of 5% when assuming a 20%…

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