Home Alzheimer’s Disease Trastuzumab Deruxtecan Shows Antitumor Activity for Patients with HER2-Overexpressing NSCLC

Trastuzumab Deruxtecan Shows Antitumor Activity for Patients with HER2-Overexpressing NSCLC

Trastuzumab deruxtecan (Enhertu) treatment demonstrated strong antitumor activity for patients with HER2-overexpressing non–small cell lung cancer (NSCLC), regardless of HER2 expression levels, according to interim findings from a cohort of the phase 2 DESTINY Lung-01 trial (NCT03505710) presented at the 2020 World Conference on Lung Cancer (WCLC) Singapore.1 

“The encouraging early efficacies support the continued exploration of [trastuzumab deruxtecan] in patients with HER2-overexpressing non–small cell lung cancer,” said Kazuhiko Nakagawa, MD, PhD, in a presentation during the International Association for the Study of Lung Cancer WCLC.

Trastuzumab deruxtecan is an antibody–drug conjugate (ADC) composed of an anti-HER2 antibody, a tetrapeptide-based linker, and a topoisomerase I inhibitor payload. The ADC earlier demonstrated promising activity in patients with…

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