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Study Suggests a High Charlson Comorbidity Index Score Negatively Impacts OS, RS in CLL

A study published in the International Journal of Environmental Research and Public Health revealed that among patients with chronic lymphocytic leukemia (CLL), a high Charlson comorbidity index (CCI) score negatively impacted overall survival (OS) and relative survival (RS).

However, when also considering age and Rai score, which indicates severity of CLL and comorbidities present at diagnosis, the effect of CCI score on mortality was found to be statistically nonsignificant for this patient population.

“These population-based data will provide insights into the relationship between comorbidities and CLL in a real-world setting,” wrote the study authors, who were led by Alicia Villavicencio.

Using the Girona Cancer Registry of Spain, the investigators extracted incident CLL cases diagnosed between 2008 and 2016. Of note, CLL and small lymphocytic lymphoma (SLL) cases were…

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