Home Alzheimer’s Disease Study Shows Promise for UGN-101 in Low-Grade Upper Tract Urothelial Cancer

Study Shows Promise for UGN-101 in Low-Grade Upper Tract Urothelial Cancer

An open-label, single-arm, phase III study published in The Lancet Oncology assessed the safety and activity of non-surgical treatment in low-grade upper tract urothelial cancer using instillation of UGN-101 (Jelmyto), a mitomycin-containing reverse thermal gel.1

The OLYMPUS study suggested that primary chemoablation of low-grade upper tract urothelial cancer with intracavitary UGN-101 resulted in clinically significant disease eradication, and may offer a kidney-sparing treatment alternative for this patient population. 

Proof-of-concept and preliminary safety data for UGN-101 were previously reported using data from a compassionate-use program which treated 22 patients with upper tract urothelial cancer.

“UGN-101 is semi-solid at body temperature and becomes a viscous liquid at colder temperatures that can be injected via a catheter passed from the bladder into the renal pelvis…

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