Home Alzheimer’s Disease Study Results Appear to Support Larotrectinib Use in NTRK+ Lung Cancer

Study Results Appear to Support Larotrectinib Use in NTRK+ Lung Cancer

Frequent and durable antitumor responses as well as extended survival were noted with the use of larotrectinib (Vitrakvi) in patients with NTRK gene fusion–positive advanced lung cancer, and these benefits extended to patients with central nervous system (CNS) metastases.1

Results were collected from 14 patients enrolled in a phase 1 (n = 1) and a phase 2 (n = 13) clinical trial (NCT02122913 and NCT02576431, respectively) of larotrectinib who received 100 mg twice daily in continuous 28-day cycles and were presented during the 2020 World Conference on Lung Cancer Singapore. Thirteen patients had non–small cell lung cancer and 1 had small cell lung cancer. Half of the patients had CNS metastases at baseline. There were 11 patients (79%) with NTRK1 fusions and 3 (21%) had tumors with NTRK2 fusions.

Larotrectinib, a first-in-class, highly selective, and CNS-active TRK inhibitor,…

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