Home Alzheimer’s Disease Study Finds Niraparib Plus Temozolomide or Irinotecan Tolerable in Pretreated Ewing Sarcoma

Study Finds Niraparib Plus Temozolomide or Irinotecan Tolerable in Pretreated Ewing Sarcoma

The phase 1 SARC025 study (NCT02044120) of the PARP1/2 inhibitor niraparib (Zejula) in combination with either temozolomide (Temodar) or irinotecan in patients with pretreated Ewing sarcoma (ES) suggested that either combination was tolerable when dose adjustments were made.

Based on these findings, SARC025 study has commenced a triple-combination study of niraparib plus temozolomide and irinotecan in this patient population.

“On the basis of preclinical data suggesting maximum synergy with the 3 agents, we hypothesize that with lower doses of all 3 agents, there may be less hematologic and gastrointestinal toxicity with the potential for synergistic efficacy,” noted the study authors who were led by Rashmi Chugh, MD. “However, whether this will offer any advantage over higher dose, standard temozolomide and irinotecan therapy remains to be determined.”

Patients enrolled in arm…

Continue Reading to the Source

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Most Popular

Patients Aged 70 or Older With Esophageal or EGJ Cancers Should Be Evaluated for Optimal Curative Therapy

Older patients with locoregional esophageal or esophagogastric junction (EGJ) cancer need to be evaluated for optimal curative therapy, including neoadjuvant chemoradiotherapy and surgical resection,...

Third COVID-19 Vaccine Earns Emergency Use Authorization Following Favorable Advisory Committee Meeting

The first single-dose COVID-19 vaccine was granted Emergency Use Authorization (EUA) by the FDA, according to its developer Janssen Pharmaceutical Companies of Johnson &...

Abiraterone Acetate, Apalutamide Likeliest to Improve Survival for Patients with Castration-Sensitive Prostate Cancer

In a comparison of systemic treatments as add-ons to androgen-deprivation therapy (ADT) for patients with metastatic castration-sensitive prostate cancer (mCSPC), abiraterone acetate (Zytiga) and...

Women of Minority Race/Ethnicity, Lower Socioeconomic Status Experience Lower Digital Breast Tomosynthesis Access

A cross-sectional study of digital breast tomosynthesis (DBT) screening published in JAMA Network Open indicated that women of minority race/ethnicity and lower socioeconomic status...

Recent Comments