An international systematic review and meta-analysis published in Cancer, titled CRiSP, suggested that stereotactic body radiation therapy (SBRT) for locally advanced pancreatic cancer (LAPC) may offer a modest improvement in overall survival (OS) compared to conventionally fractioned radiation therapy with concurrent chemotherapy (CFRT), with a more favorable toxicity profile.
However, the researchers noted that further studies assessing the use of SBRT for patients with LAPC are needed to improve outcomes for this patient population.
“There is currently no well-defined standard of care in the management of patients with LAPC,” the authors wrote. “This is the first meta-analysis to compare SBRT with CFRT for LAPC.”
Using a PICOS/PRISMA/MOOSE selection protocol, the researchers identified studies that fit their inclusion criteria. Inclusion criteria included patients…