Savolitinib showed encouraging efficacy data and an improved safety profile compared to the standard of care sunitinib (Sutent) in patients with MET-driven papillary renal cell carcinoma (RCC), according to study results presented at the 2020 ASCO Virtual Scientific Program.
The highly selective MET-tyrosine kinase inhibitor also yielded fewer grade 3 or 4 adverse events (AEs) while requiring fewer dose modifications than sunitinib, which performed more poorly than the external retrospective data anticipated.
“Although patient numbers and follow-up were limited, savolitinib demonstrated encouraging efficacy and an improved safety profile versus sunitinib,” said lead study author Toni K Choueiri, MD, director, Lank Center for Genitourinary Oncology and the Kidney Cancer Center, Dana-Farber Cancer Institute, in his presentation of the data.
Median progression-free survival (PFS)…
