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ROS1+ Metastatic NSCLC Sees Early Benefit With Repotrectinib

Repotrectinib (TPX-0005), a next-generation tyrosine kinase inhibitor (TKI) with activity against ROS1 and TRK, was able to induce good objective responses as well as maintain a favorable safety profile in patients with non–small cell lung cancer (NSCLC) harboring ROS1 fusions.1

These data from updated preliminary findings of the phase 2 expansion 1 (EXP-1) cohort of the ongoing phase 1/2 TRIDENT-1 clinical trial (NCT03093116) were presented virtually at the 2020 World Conference on Lung Cancer (WCLC) Singapore.

“Preliminary TRIDENT-1 data are very encouraging and support repotrectinib as a potential best-in-class treatment in ROS1-positive advanced NSCLC,” Byoung Chul Cho, MD, PhD, a professor at the Yonsei Cancer Center and Severance Hospital, said in a presentation of the data.

Earlier interim data from a cohort of 11 patients in phase 1 of the TRIDENT-1 trial were…

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