Home Alzheimer’s Disease Robert J. Motzer, MD, on the Results of the Phase 3 CLEAR...

Robert J. Motzer, MD, on the Results of the Phase 3 CLEAR Trial for Advanced RCC

Results from the phase 3 CLEAR trial (NCT02811861), presented at the 2021 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium, found that compared with sunitinib (Sutent), combination treatment with lenvatinib (Lenvima) and pembrolizumab (Keytruda) demonstrated significant improvements in progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) among patients with advanced renal cell carcinoma (RCC). Additionally, combination treatment with lenvatinib plus everolimus (Afinitor) demonstrated significant improvements in PFS and ORR within this patient population.

Importantly, the safety profile of each combination was also found to be manageable and consistent with the known single-agent profiles.

In this study, participants were randomized 1:1:1 to receive either lenvatinib plus pembrolizumab, lenvatinib plus everolimus, or…

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