Home Alzheimer’s Disease Researchers Develop Long Noncoding RNA-Based Immune Classes and Scores for Immunotherapy

Researchers Develop Long Noncoding RNA-Based Immune Classes and Scores for Immunotherapy

Immunotherapy is recommended for patients with bladder cancer that fall into the immune-active class, including 1 of the 4 distinct long noncoding RNA-based immune classes identified by trial researchers, according to a study published in JAMA Network Open.

The study also recommends that the long noncoding RNA score should be integrated into multiomic panels composed of tumor alteration burden, PD-L1 expression, cytotoxic T-lymphocyte (CTL) infiltration to act as a useful biomarker for precision immunotherapy.

“This study used signatures of (long noncoding RNAs) and CTL infiltration to identify 4 distinct immune classes in clinical cancer immunotherapy and recommends immunotherapy for patients in the immune-active class with both an immune-functional lncRNA signature and dense CTL infiltration,” wrote the researchers.

A total of 419 patients were analyzed, including 348 patients…

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