Home Alzheimer’s Disease Prevalence of Pathogenic Variants in Postmenopausal Breast Cancer

Prevalence of Pathogenic Variants in Postmenopausal Breast Cancer

Data on the prevalence of pathogenic variants (PV) in breast cancer susceptibility genes among postmenopausal women, published in a research letter in JAMA, suggest that PV prevalence among this population may be high enough to warrant testing even in the absence of early diagnosis age or family history.1

Researchers suggested that these finding should inform testing guidelines, as currently most guidelines don’t address testing postmenopausal women with breast cancer in the absence of other risk factors. 

“There’s been a lot of controversy in the field as to whether every woman with breast cancer should receive genetic testing, in part because we didn’t know how prevalent cancer-associated mutations are in this largest subgroup of newly diagnosed people – that is, women who develop breast cancer after menopause without the presence of any known hereditary risk…

Continue Reading to the Source


Please enter your comment!
Please enter your name here

Most Popular

Cause of Alzheimer’s disease traced to mutation in common enzyme

submitted by /u/scotsman81 Continue Reading to the Source

Reflections on Living With an Incurable Illness : braincancer

(I’ve checked with the moderators to make sure this is appropriate and a good fit for this subreddit. I'm a very private person, and...

This Foramen Magnum Meningioma almost killed me 18 years ago.

submitted by /u/dkrem Continue Reading to the Source

Patients, Family & Friends, and Healthcare professionals : braincancer

I am currently a PhD student based at the Marie Curie Palliative Care Research Centre at Cardiff University. My PhD is focussed on developing...

Recent Comments