Home Alzheimer’s Disease Preemptive Tocilizumab Decreases CRS After Tisagenlecleucel Administration in Pediatric B-Cell ALL

Preemptive Tocilizumab Decreases CRS After Tisagenlecleucel Administration in Pediatric B-Cell ALL

Among patients with pediatric B-cell acute lymphoblastic leukemia (ALL), a prospective clinical trial (NCT02906371) found that risk-adapted preemptive tocilizumab (PT; Actemra) administration resulted in a decrease in the anticipated incidence of grade 4 cytokine release syndrome (CRS), meeting the study end point, without adversely impacting the antitumor efficacy or safety of tisagenlecleucel (Kymriah).1

In the time since this trial was initiated, tisagenlecleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy, has received FDA approval and is now available at some treatment centers.2 Thus, these study results, published in the Journal of Clinical Oncology, are applicable to a variety of patients who are at risk for severe CRS.

“CRS is the most common severe toxicity associated with CAR T-cells,” wrote the study authors, led by Stephan Kadauke, MD, PhD. “As…

Continue Reading to the Source

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Most Popular

Patients Aged 70 or Older With Esophageal or EGJ Cancers Should Be Evaluated for Optimal Curative Therapy

Older patients with locoregional esophageal or esophagogastric junction (EGJ) cancer need to be evaluated for optimal curative therapy, including neoadjuvant chemoradiotherapy and surgical resection,...

Third COVID-19 Vaccine Earns Emergency Use Authorization Following Favorable Advisory Committee Meeting

The first single-dose COVID-19 vaccine was granted Emergency Use Authorization (EUA) by the FDA, according to its developer Janssen Pharmaceutical Companies of Johnson &...

Abiraterone Acetate, Apalutamide Likeliest to Improve Survival for Patients with Castration-Sensitive Prostate Cancer

In a comparison of systemic treatments as add-ons to androgen-deprivation therapy (ADT) for patients with metastatic castration-sensitive prostate cancer (mCSPC), abiraterone acetate (Zytiga) and...

Women of Minority Race/Ethnicity, Lower Socioeconomic Status Experience Lower Digital Breast Tomosynthesis Access

A cross-sectional study of digital breast tomosynthesis (DBT) screening published in JAMA Network Open indicated that women of minority race/ethnicity and lower socioeconomic status...

Recent Comments