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Phase I/II Trial To Evaluate Dual HER2 Combination Therapy in HR+, HER2+ Breast Cancer

A phase I/II clinical trial presented at the American Association for Cancer Research (AACR) Annual Virtual Meeting 2020, held April 27-28, 2020, will examine the safety and efficacy of dual HER2 therapy in combination with palbociclib (Ibrance) and anastrozole (Arimidex).1

“Treatment with chemotherapy remains the standard of care in those with newly diagnosed metastatic, triple-positive breast cancer,” Krystal P. Cascetta, MD, assistant professor of Medicine, Hematology, and Medical Oncology at the Tisch Cancer Institute at Mount Sinai, said in a poster presentation of the trial at AACR.2

The multicenter trial will consist of 2 phases, with phase I determining the maximum tolerated dose (MTD) of palbociclib and phase II determining the clinical benefit rate (CBR) of treatment with anastrozole, palbociclib, trastuzumab (Herceptin), and pertuzumab (Perjeta). The clinical benefit…

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