Home Alzheimer’s Disease Personalized Blood Test Improves MRD Detection in Patients with Breast Cancer

Personalized Blood Test Improves MRD Detection in Patients with Breast Cancer

A study, published in Clinical Cancer Research, found that tracking large numbers of individualized tumor mutations in cell-free DNA (cfDNA) can improve minimal residual disease (MRD) detection in patients with breast cancer; however, its sensitivity is driven by the number of tumor mutations available to track.1

Given these findings, researchers predict that tracking even more mutations might increase assay sensitivity without compromising specificity, with studies currently underway. 

“By taking an individualized approach – searching for many mutations that are specific to one patient’s cancer – we could greatly increase our sensitivity to detect traces of cancer DNA in patients who had completed their initial treatment plan,” senior author Viktor Adalsteinsson, PhD, associate director of the Gerstner Center at the Broad Institute, said in a press release.2 “And with…

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