Home Alzheimer’s Disease Pembrolizumab Plus Chemoradiation Therapy Yields Promising Results for Patients with Unresectable, Locally...

Pembrolizumab Plus Chemoradiation Therapy Yields Promising Results for Patients with Unresectable, Locally Advanced NSCLC

The combination of pembrolizumab (Keytruda) plus concurrent chemoradiation therapy (cCRT) showed antitumor activity in patients with unresectable, locally advanced, stage III non–small cell lung cancer (NSCLC), regardless of PD-L1 status or tumor histology, according to follow up data presented at the International Association for the Study of Lung Cancer 2020 World Conference on Lung Cancer (WCLC) Singapore.1

The phase 2 KEYNOTE-799 study (NCT03631784) enrolled a total of 216 patients with previously untreated, unresectable, pathologically confirmed stage IIIA–C NSCLC, with measurable disease per RECIST 1.1. Cohort A consisted of patients with both squamous and nonsquamous NSCLC, while cohort B included patients with nonsquamous NSCLC only.

All patients enrolled in the study received up to 17 cycles of pembrolizumab, administered at a dose of 200 mg, 3 times per week. Patients in…

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