A comprehensive spectrum of partner and localizer BRCA2 (PALB2) germline mutations and characteristics of PALB2-related breast cancer in China were revealed, according to a recent study published in Cancer.
While PALB2 germline mutations confer a moderately increased risk for breast cancer, these mutations “profoundly increase breast cancer risk” for patients aged 30 years old or younger in this Chinese population.
“This study has revealed a comprehensive spectrum of PALB2 germline mutations and characteristics of PALB2-related breast cancer in China,” wrote the researchers. “PALB2 germline mutations conferred a moderately increased risk for breast cancer but profoundly increased breast cancer risk for those aged 30 years or younger.”
Overall, deleterious PALB2 mutation carriers accounted for 0.97% (n = 160) in the main breast cancer cohort and for 0.19% (n =…