Home Alzheimer’s Disease Optimizing Treatment for Patients with Metastatic Pancreatic Cancer, DNA Repair Defects

Optimizing Treatment for Patients with Metastatic Pancreatic Cancer, DNA Repair Defects

A study published in Clinical Cancer Research found that patients with metastatic pancreatic cancer who had germline or somatic mutations in DNA repair genes had superior clinical outcomes after platinum-based chemotherapy, as compared to patients without these mutations.1

Moreover, biallelic mutation of homologous recombination (HR) genes showed the best association with this genomic characteristic, independent of germline versus somatic origin. Given these findings, researchers indicated that determining the homologous recombination deficiency (HRD) status is ideally needed at the time of diagnosis to optimize survival and refine treatment selection for this patient population.

“Our data support the use of platinum-based chemotherapy as first-line treatment for patients with defects in various HR genes,” senior author Eileen O’Reilly, MD, medical oncologist at Memorial Sloan…

Continue Reading to the Source

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Most Popular

Parasite found in undercooked meat linked with risk of rare brain cancer

submitted by /u/Meat_Mithkabob Continue Reading to the Source

Living up to expectations : braincancer

Hey everyone!I wrote a little something about some of the comments you often hear from others and how sometimes you feel like you need...

My Brain Tumor Taught Me To Shift My Perspective on These 5 Things

submitted by /u/andrewjoegeorge Continue Reading to the Source

Recent Comments