Home Alzheimer’s Disease Newly Diagnosed Acute GVHD Shows Benefit With Itolizumab Use

Newly Diagnosed Acute GVHD Shows Benefit With Itolizumab Use

The treatment landscape for patients with newly diagnosed acute graft-versus-host disease (GVHD) may improve with the use of a humanized IgG1 monoclonal antibody that modulates the activated leukocyte cell adhesion molecule (ALCAM) pathway called itolizumab.

Data from the multicenter, dose-ascending phase 1b/2 EQUATE study (NCT03763318) that were presented during the virtual 2021 Transplantation & Cellular Therapy Meetings showed that administration of itolizumab resulted in a dose-dependent reduction of CD6 expression on T-effector cells. Additionally, a 100% overall response rate (ORR) at the 2 highest dose levels at day 29 was observed, with almost all responses being complete responses, said lead study author John Koreth, MBBS, PhD.

“The dose-dependent reduction of CD6 expression on CD4+ and CD8+ T cells is consistent with the expected mechanism of action [of itolizumab],” said…

Continue Reading to the Source


Please enter your comment!
Please enter your name here

Most Popular

Lower-Dose Hypofractionated Radiotherapy Schedule Proves Effective for Patients With Locally Advanced Bladder Cancer

Using a hypofractionated schedule of 55 Gy in 20 fractions over 4 weeks to treat patients with locally advanced bladder cancer was noninferior to...

Study Identifies New Biomarker Which Could Predict Response to CD40 Immunotherapy in Pancreatic Cancer

Research published in JCI Insight identified systemic inflammation as a possible resistance mechanism to a CD40–based chemoimmunotherapy in patients with advanced pancreatic cancer.1According to...

Significant Interfacility Variation Found in Implementation of Low-Value Breast Cancer Procedures

A number of facility-level characteristics were associated with the use of low-value breast cancer procedures, and interfacility variation presented an opportunity for formal de-implementation...

KarMMa Trial Results for Ide-Cel in Refractory Myeloma Show Favorable Efficacy

Chimeric antigen receptor (CAR) T-cell therapy with idecabtagene vicleucel (ide-cel) induced responses in almost 75% of patients with multiple myeloma following relpase on multiple...

Recent Comments