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Methods for Assessing Familial Breast Cancer Risk Depend on Study Purpose

A study, published in Cancer, found that the choice of method for assessing familial breast cancer risk should depend on the purpose of the study, with the accumulative method being the most convenient in practice and the least favored for risk prediction, the static method being suitable for etiological impact and risk attribution studies, and the dynamic method being better suited for risk stratification studies. 

Given this finding, the researchers suggested that studies aiming at risk stratification and the identification of high-risk women for early preventive interventions, such as personalized cancer prevention and risk-adapted screening strategies, should consider the timing of breast cancer events in family members, especially if they have early-onset or premenopausal breast cancer. 

“Because each of these methods required a different set of variables in the data…

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