A multicenter phase II study of venetoclax (Venclexta) plus dose-adjusted R-EPOCH (rituximab [Rituxan], etoposide phosphate [Etopophos], prednisone [Rayos], vincristine sulfate [Marqibo], cyclophosphamide, and doxorubicin hydrochloride) in patients with chronic lymphocytic leukemia (CLL) who developed Richter’s Syndrome found the treatment combination to be effective in this patient population.
Based on the study results, presented at the 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program, Matthew Steven Davids, MD, MMSc, an attending physician in the Lymphoma Program of the Division of Hematologic Malignancies at the Dana-Farber Cancer Institute, along with his fellow investigators believe that this novel approach is worthy of further study in patients who develop Richter’s Syndrome. Moreover, a future study expansion of venetoclax plus CHOP…
