Results from the randomized, open-label, phase 3 SOPHIA trial (NCT02492711) suggest that among patients with pretreated ERBB2-positive advanced breast cancer, a disease that is typically incurable, margetuximab (Margenza) plus chemotherapy resulted in a statistically significant improvement in progression-free survival (PFS) compared with trastuzumab (Herceptin) plus chemotherapy following progression on 2 or more prior anti-ERBB2 therapies.1
The study, published in JAMA Oncology, also indicated that margetuximab plus chemotherapy had an acceptable safety profile which was comparable to that observed with trastuzumab plus chemotherapy.
“Alternatives for this patient population include neratinib [Nerlynx], tucatinib [Tukysa], and trastuzumab deruxtecan [Enhertu], which have emerged as active regimens, albeit with different levels of effectiveness, and all with notable toxic…
