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Kidney Cancer Destination Could Guide Treatment Decisions Moving Forward

Renal cell carcinoma (RCC) that metastasizes in the pancreas is characterized by a different biology than kidney cancers that metastasize elsewhere, heightened angiogenesis, and an uninflamed stroma, according to a study published in JCI Insight.1-2

These characteristics are likely credited for RCC’s good prognosis, sensitivity to antiangiogenic therapies, and refractoriness to immune checkpoint inhibitors. Along with this, RCC also possesses characteristics that can influence successful treatment.

“Gene expression analyses revealed limited evolution and an angiogenic signature, which together with histopathological studies, provide a potential explanation for the differential treatment responsiveness,” wrote the researchers.1“Overall, these findings suggest that tumors that metastasize to the pancreas represent a distinct clade of (clear cell renal cell carcinoma), even if…

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