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JSP191 With Low Dose Irradiation and Fludarabine is Safe and Effective for Patients with MRD+ AML/MDS

JSP191 combined with low dose total body irradiation (TBI) and fludarabine is a safe, well-tolerated treatment option capable of clearing minimal residual disease (MRD)–positive acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in older adult patients undergoing nonmyeloablative allogeneic hematopoietic cell transplantation (HCT), according to a poster presented at the 2021 Transplantation and Cellular Therapy Meetings.

While the results of this phase 1 trial (NCT04429191) are early, the investigators emphasized that these data are the first to demonstrate that the antiCD117 monoclonal antibody is safe and effective in this disease cohort.

“We are developing a first-in-class monoclonal antibody (mAb), JSP191, which targets and depletes normal and MDS/AML disease-initiating hematopoietic stem cells,” wrote the investigators. “JSP191 acts by inhibiting stem cell…

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