Home Alzheimer’s Disease JNJ-4528 Continues to Show Durable Responses in Relapsed/Refractory Multiple Myeloma

JNJ-4528 Continues to Show Durable Responses in Relapsed/Refractory Multiple Myeloma

JNJ-4528, a chimeric antigen receptor (CAR) T-cell therapy, continued to demonstrate deep and durable responses in heavily pretreated patients with relapsed/refractory multiple myeloma, according to updated findings from the phase 1b/2 CARTITUDE-1 (NCT03548207) trial presented during 2020 American Society of Clinical Oncology (ASCO) Virtual Scientific Program.1

Lead author Jesus G. Berdeja, MD, reported that the overall response rate (ORR) was 100%, with a stringent complete response (sCR) rate of 86% (25 out of 29 patients). Further, the progression-free survival (PFS) rate was 86% (95% CI, 67%-95%) at 9 months. Results were 

The objective of the phase 1b portion of CARTITUDE-1 was to determine the safety of the B-cell maturation antigen (BCMA) and confirm the dose for future research. Phase 2 is investigating the efficacy in terms of ORR, defined by the International Myeloma…

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