Home Alzheimer’s Disease HER3-Directed Antibody Therapy May Be an Effective Strategy in EGFR+ NSCLC

HER3-Directed Antibody Therapy May Be an Effective Strategy in EGFR+ NSCLC

According to findings from a phase 1 study (NCT03260491), the antibody-drug conjugate patritumab deruxtecan (U3-1402) induced clinically meaningful antitumor activity and a manageable safety profile in pretreated patients with metastatic or unresectable EGFR-mutant non–small cell lung cancer (NSCLC).1

These data that were presented during the 2020 World Conference on Lung Cancer Singapore showed that the HER3-directed agent administered at the recommended expansion dose of 5.6 mg/kg resulted in a confirmed objective response rate per blinded independent central review of 25% (n = 14; 95% CI, 14.4%-38.4%), which consisted of a 2% complete response rate (n = 1) and a 23% partial response rate (n = 13). The stable disease rate was 45% (n = 25).

Results were from the April 30, 2020 data cutoff, by which time 57 patients with EGFR-mutant disease from the dose-escalation and dose-expansion…

Continue Reading to the Source


Please enter your comment!
Please enter your name here

Most Popular

Patients Aged 70 or Older With Esophageal or EGJ Cancers Should Be Evaluated for Optimal Curative Therapy

Older patients with locoregional esophageal or esophagogastric junction (EGJ) cancer need to be evaluated for optimal curative therapy, including neoadjuvant chemoradiotherapy and surgical resection,...

Third COVID-19 Vaccine Earns Emergency Use Authorization Following Favorable Advisory Committee Meeting

The first single-dose COVID-19 vaccine was granted Emergency Use Authorization (EUA) by the FDA, according to its developer Janssen Pharmaceutical Companies of Johnson &...

Abiraterone Acetate, Apalutamide Likeliest to Improve Survival for Patients with Castration-Sensitive Prostate Cancer

In a comparison of systemic treatments as add-ons to androgen-deprivation therapy (ADT) for patients with metastatic castration-sensitive prostate cancer (mCSPC), abiraterone acetate (Zytiga) and...

Women of Minority Race/Ethnicity, Lower Socioeconomic Status Experience Lower Digital Breast Tomosynthesis Access

A cross-sectional study of digital breast tomosynthesis (DBT) screening published in JAMA Network Open indicated that women of minority race/ethnicity and lower socioeconomic status...

Recent Comments