Home Alzheimer’s Disease HER3-Directed Antibody Therapy May Be an Effective Strategy in EGFR+ NSCLC

HER3-Directed Antibody Therapy May Be an Effective Strategy in EGFR+ NSCLC

According to findings from a phase 1 study (NCT03260491), the antibody-drug conjugate patritumab deruxtecan (U3-1402) induced clinically meaningful antitumor activity and a manageable safety profile in pretreated patients with metastatic or unresectable EGFR-mutant non–small cell lung cancer (NSCLC).1

These data that were presented during the 2020 World Conference on Lung Cancer Singapore showed that the HER3-directed agent administered at the recommended expansion dose of 5.6 mg/kg resulted in a confirmed objective response rate per blinded independent central review of 25% (n = 14; 95% CI, 14.4%-38.4%), which consisted of a 2% complete response rate (n = 1) and a 23% partial response rate (n = 13). The stable disease rate was 45% (n = 25).

Results were from the April 30, 2020 data cutoff, by which time 57 patients with EGFR-mutant disease from the dose-escalation and dose-expansion…

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