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Genetic Patterns Could Help Doctors Identify Ultra High Risk Patients of Multiple Myeloma

Researchers found a new test that could help doctors pick out patients with multiple myeloma whose cancers have high-risk genetic features to determine they are at ‘ultra high risk’ of early and aggressive cancer progression, according to a recent study published in Leukemia.1

Specific genetic patterns were shown to have a poorer survival rate than average, resulting in little benefit from treatment with the drug lenalidomide. The test allows for clinicians to direct patients to alternative treatment options if it shows patients are unlikely to respond to the standard treatment.

“Our results demonstrate that patients with double-hit or GEP high-risk status are unlikely to benefit from current treatment approaches, including single agent lenalidomide maintenance therapy,” wrote the researchers. “In such patients intensified ongoing therapy with combination agents may be…

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