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Genes May Predict Cancer Patients at Risk of Chemo Brain

In a study published in the Journal of Clinical Oncology, researchers found associations between global cognitive impairment in patients with hematologic malignancies treated with blood or marrow transplantation (BMT) and genetic mechanisms that influence DNA repair, BBB, and telomere homeostasis.1

Additionally, significant single nucleotide polymorphisms (SNPs) were found to enhance the risk prediction model performance beyond standard demographic and clinical factors.

“A better understanding of post-BMT health care needs could result in targeted strategies that yield better quality of survival and reduced utilization of health care resources,” senior author Smita Bhatia, MD, MPH, from the University of Alabama at Birmingham’s (UAB) Institute for Cancer Outcomes and Survivorship, said in a press release.2

In a discovery cohort of 277 subjects, BMT recipients underwent a…

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