Home Alzheimer’s Disease First-Line Nivolumab Plus Ipilimumab Improves OS Versus Chemo in Patients with Metastatic...

First-Line Nivolumab Plus Ipilimumab Improves OS Versus Chemo in Patients with Metastatic Uveal Melanoma

A phase 2 study published in the Journal of Clinical Oncology found that in the first-line setting for patients with metastatic uveal melanoma, nivolumab (Opdivo) plus ipilimumab (Yervoy) demonstrated a modest improvement in overall survival compared with historical benchmarks of chemotherapy.

In addition, the toxicity profile of the treatment combination was found to be manageable and did not differ from that in observed in patients with cutaneous melanoma, for which treatment with nivolumab plus ipilimumab is already approved.

“These results provide a strong rationale for further research on immunotherapy treatment combinations in [uveal melanoma],” wrote the study authors, who were led by José María Piulats, MD, PhD.

In this multicenter, open-label, single-arm phase 2 trial (NCT02626962) led by the Spanish Multidisciplinary Melanoma Group (GEM), treatment-naïve patients who…

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