Home Alzheimer’s Disease FDA Approves Rucaparib for Adult Patients with BRCA+ mCRPC

FDA Approves Rucaparib for Adult Patients with BRCA+ mCRPC

The FDA approved rucaparib (Rubraca) for the treatment of adult patients with a deleterious BRCA mutation (germline and/or somatic)-associated metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor-directed therapy and a taxane-based chemotherapy. 

This indication was approved under accelerated approval based on the objective response rate (ORR) and duration of response (DOR) data observed in the multi-center, single arm TRITON2 clinical trial.

“Standard treatment options for men with mCRPC have been limited to androgen receptor-targeting therapies, taxane chemotherapy, Radium-223 and sipuleucel-T,” Wassim Abida, MD, medical oncologist at Memorial Sloan Kettering Cancer Center and principal investigator for the TRITON2 study, said in a press release. “[Rucaparib] is the first in a class of drugs to become newly available to…

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