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Data Reveals DNA Variations that Alter Breast Cancer Risk in Women

Data revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer, according to a study published in Nature Genetics.

This analysis of genetic studies covering 266,000 women is the first to link these specific risk variants to multiple, detailed subtypes of breast cancer.

“The findings from this analysis enhance our understanding of the biology that differentiates subtypes and may improve our ability to predict women’s breast cancer risks, even at the level of specific breast cancer subtype,” said corresponding author Nilanjan Chatterjee, PhD, in a press release.

Of the 32 new risk variants identified by researchers, 15 were also independently linked to 1 or more specific breast cancer subtypes. Of that specific set of 15 variants, 7 were linked to estrogen receptor status, 7 to tumor grade, 4 to HER2 receptor status, and…

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