Home Alzheimer’s Disease CheckMate-743 Trial of Nivolumab, Ipilimumab Meets Primary Endpoint in Mesothelioma Trial

CheckMate-743 Trial of Nivolumab, Ipilimumab Meets Primary Endpoint in Mesothelioma Trial

The CheckMate-743 trial evaluating nivolumab (Opdivo) in combination with ipilimumab (Yervoy) in previously untreated malignant pleural mesothelioma met its primary endpoint of overall survival (OS), according to Bristol-Myers Squibb, the agent’s developer.1

Based on a pre-specified interim analysis conducted by an independent data monitoring committee, the combination treatment was also found to result in a statistically significant and clinically meaningful improvement in OS compared to chemotherapy (pemetrexed and cisplatin or carboplatin). Additionally, the safety profile of nivolumab plus ipilimumab observed in the trial reflects the known safety profile of the combination. 

“Malignant pleural mesothelioma is a devastating disease that has seen limited treatment advances over the past decade,” Sabine Maier, MD, development lead of thoracic cancers at Bristol Myers Squibb,…

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