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Aspirin Use Beginning Before and Continuing After Age 70 Reduces Risk of CRC

A pooled analysis of 2 cohort studies published in JAMA Oncology revealed that instituting aspirin into the treatment regimen of elderly adults was not associated with a lower risk of colorectal cancer (CRC). Instead, the study indicated that individuals who began using aspirin before age 70 years and continued using the agent later in life had a reduced risk of CRC.

Notably, previously reported findings from the randomized Aspirin in Reducing Events in the Elderly (ASPREE) study evaluated 19,114 relatively healthy adults aged 70 years or older (or 65 years or older for racial/ethnic minorities) and reported that patients assigned to daily low-dose aspirin had an increased risk of death from cancer, including CRC, without a corresponding increase in overall and CRC incidence. However, the majority of these study participants had never used aspirin regularly before study…

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