Home Alzheimer’s Disease Amivantamab Shows Promise in NSCLC With Hard-to-Treat EGFR Mutation Subtype

Amivantamab Shows Promise in NSCLC With Hard-to-Treat EGFR Mutation Subtype

In patients receiving amivantamab (formerly JNJ-6372) for previously treated non–small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations, deep and durable responses as well as promising survival were reported at the 2020 World Conference on Lung Cancer (WCLC) Singapore from the phase 1 CHRYSALIS trial (NCT02609776).1

Of note, 63% of patients who achieved responses maintained their response for at least 6 months and 47% remained on therapy after a median follow-up of over 9 months.

“There is a significant need for new treatment options for patients with NSCLC and EGFR exon 20 insertion mutations whose disease generally does not respond well to chemotherapy and the tyrosine kinase inhibitors [TKIs] used to treat other EGFR mutations,” Joshua K. Sabari, MD, presenting investigator from New York University Langone’s Perlmutter Cancer Center, said in a press…

Continue Reading to the Source


Please enter your comment!
Please enter your name here

Most Popular

Robert J. Motzer, MD, on the Rationale for the Phase 3 CheckMate 9ER Trial in Advanced RCC

Compared with sunitinib (Sutent), combination treatment with nivolumab and cabozantinib demonstrated improved efficacy and prolonged survival among patients with previously treated advanced renal cell...

PHERGain II Trial Launched to Examine Chemotherapy-Free Treatment for Patients With HER2+ Breast Cancer

A clinical trial to support the use of a chemotherapy-free therapeutic approach has been launched and will aim to demonstrate that this approach is...

FDA Grants Breakthrough Therapy Designation to Tipifarnib for Treatment of HRAS-Mutant HNSCC

The FDA has granted breakthrough therapy designation to the investigational drug tipifarnib for the treatment of patients with recurrent or metastatic HRAS-mutant head and...

Treatment with PARP Inhibitors Increased Risk of Myelodysplastic Syndrome and Acute Myeloid Leukemia

Patients treated with PARP inhibitors saw an increased risk of myelodysplastic syndrome and acute myeloid leukemia (AML) versus patients treated with placebo, according to...

Recent Comments