Frontline treatment failure of platinum-based therapy may be followed by liposomal irinotecan in SCLC according to data from the first phase of the RESILIENT trial (NCT03088813) presented at the 2020 World Conference on Lung Cancer showing promising antitumor activity and safety with this strategy.
The study authors initiated the 2-part phase 2/3 open-label, single-arm study to assess liposomal irinotecan in patients with SCLC whose disease progressed after receiving platinum-based chemotherapy in the frontline. Treatment options in the second-line setting remain limited but analyzing long-term follow-up data demonstrated that both exploratory doses of liposomal irinotecan were effective and tolerable in patients with SCLC. Patients who were older than 18, had an ECOG performance score of 0 or 1, and had previously progressed on platinum-based treatments were eligible for the study….
