Patients who underwent adjuvant radiotherapy (RT) after resection of distal cholangiocarcinoma (dCCA) experienced a survival benefit, even in those with margin-negative or node-negative resections, according to data published in Cancer.
Because of this survival benefit association, the investigators suggest that adjuvant RT be considered routinely after resection of dCCA, regardless of margin and nodal status.
“In this large national registry analysis including 8233 patients, adjuvant RT after resected dCCA was associated with improved survival after multivariable adjustment and accounting for treatment-selection bias,” wrote the investigators. “Subset analyses revealed that this benefit was maintained irrespective of pathological nodal and margin status.”
After propensity score matching was used to account for treatment-selection bias, adjuvant therapy was associated with…